Supplementary material available via the World Wide Web.

The Foundations of Biochemistry -- I. STRUCTURE AND CATALYSIS. Water -- Amino Acids, Peptides, and Proteins -- The Three-Dimensional Structure of Proteins -- Protein Function -- Enzymes -- Carbohydrates and Glycobiology -- Nucleotides and Nucleic Acids -- DNA-Based Information Technologies -- Lipids -- Biological Membranes and Transport -- Biosignaling -- II. BIOENERGETICS AND METABOLISM. Bioenergetics and Biochemical Reaction Types -- Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway -- Principles of Metabolic Regulation -- The Citric Acid Cycle-- Fatty Acid Catabolism -- Amino Acid Oxidation and the Production of Urea -- Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation -- Carbohydrate Biosynthesis in Plants and Bacteria -- Lipid biosynthesis -- Biosynthesis of Amino Acids, Nucleotides, and Related Molecules -- Hormonal Regulation and Integration of Mammalian Metabolism -- III. INFORMATION PATHWAYS. Genes and Chromosomes -- DNA Metabolism -- RNA Metabolism -- Protein Metabolism -- Regulation of Gene Expression.