000			01843cam a2200313 i 4500
020			_a9781849736664
020			_a1849736669
050	0	0	_aQP552.M64 _bI54
245	0	0	_aInhibitors of molecular chaperones as therapeutic agents /
300			_axvi, 425p. _bill.
520			_aThis book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.--
650		0	_aMolecular chaperones
650		0	_aPharmaceutical chemistry
650		0	_aCancer
650	1	2	_aMolecular Chaperones
650	2	2	_aDrug Discovery.
650	2	2	_aMolecular Chaperones
650	1	7	_aMolecular Chaperones
650	2	7	_aDrug Discovery.
650	2	7	_aMolecular Chaperones
650		7	_aCancer
650		7	_aMolecular chaperones.
650		7	_aPharmaceutical chemistry.
650		7	_aMolécules chaperonnes.
650		7	_aHealth and Wellbeing.
700	1		_aMachajewski, Timothy D.,
700	1		_aGao, Zhenhai,(editor)
942			_cBK
999			_c3060 _d3060